Randomized, placebo‐controlled trial of incobotulinumtoxina for upper‐limb post‐stroke spasticity

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Randomized, placebo‐controlled trial of incobotulinumtoxina for upper‐limb post‐stroke spasticity

INTRODUCTION Efficacy and safety of incobotulinumtoxinA in post-stroke upper-limb spasticity were studied. METHODS Subjects randomized 2:1 to incobotulinumtoxinA (fixed dose 400 U) or placebo, with fixed doses for the primary target clinical pattern (PTCP; flexed elbow, 200 U; flexed wrist, 150 U; clenched fist, 100 U). Doses for non-primary patterns were flexible within predefined ranges. ...

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Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity.

Spasticity is a common disabling symptom for several neurological conditions. Botulinum toxin type A injection represents the gold standard treatment for focal spasticity after stroke showing efficacy, reversibility, and low prevalence of complications. In recent years, incobotulinumtoxinA, a new Botulinum toxin type A free of complexing proteins, has been used for treating several movement dis...

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Poststroke spasticity management.

P oststroke spasticity (PSS) is a common complication associated with other signs and symptoms of the upper motor neuron syndrome, including agonist/antagonist co-contraction, weakness, and lack of coordination. Together, they result in impairments and functional problems that can predispose to costly complications. The goal of PSS management should take into consideration not only reduction of...

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Botulinum toxin in poststroke spasticity.

Poststroke hemiparesis, together with abnormal muscle tone, is a major cause of morbidity and disability. Although most hemiparetic patients are able to reach different ambulatory levels with rehabilitation efforts, upper and lower limb spasticity can impede activities of daily living, personal hygiene, ambulation and, in some cases, functional improvement. The goals of spasticity management in...

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Electroacupuncture for poststroke spasticity (EAPSS): protocol for a randomised controlled trial

INTRODUCTION Spasticity is a common complication of stroke. Current therapies for poststroke spasticity (PSS) have been reported to be associated with high costs, lack of long-term benefit and unwanted adverse events (AEs). Electroacupuncture (EA) has been used for PSS, however, its efficacy and safety is yet to be confirmed by high-quality clinical studies. This study is designed to evaluate t...

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ژورنال

عنوان ژورنال: Muscle & Nerve

سال: 2015

ISSN: 0148-639X,1097-4598

DOI: 10.1002/mus.24776